p63 1,0 mL
Specificity and Comments:
p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. P63 is detected in prostate basal cells in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of prostate gland and can be used in a panel of antibodies such as HMW CK (34ßE12), PSA and PSAP. P63 may play a significant role in prostate development by maintaining a prostate stem cell population. Striated muscle staining may be observed with p63.
Species Reactivity: Human, mouse and rat
Clone: BC4A4
Isotype: IgG2a /?
Immunogen:
Recombinant human protein derived from aa 1-205 of human p63
Known Applications: Immunohistochemistry (formalin–fixed paraffin-embedded tissues).
Positive Control: Normal prostate
Cellular Localization: Nuclear
Supplied As:
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.