Calretinin is a calcium binding protein
that is related to calmodulin and calbindin-D28k and is found mainly in neuronal
tissue. It is present in subsets of neurons throughout the brain and spinal
chord, including sensory ganglia. Studies have shown that calretinin, like
calbindin, may be neuroprotective. Immunohistochemical studies have also
recently shown calretinin to be useful in distinguishing mesotheliomas from lung
adenocarcinomas. However, it is recommended that a panel of antibodies be used
in tandem with calretinin. Other antibodies recommended are CK 5/6, E-cadherin,
WT -1, CEA, B72.3, Vimentin and D2-40. Calretinin does not mark all
mesotheliomas (80-90%).