PTEN (M) 0,1 mL
Specificity and Comments: PTEN gene is a recently discovered tumor supressor gene that maps to chromosome 10q23. It is of longstanding interest to those studying somatic mutations in human tumors. PTEN, a novel tumor supressor, functions as a regulator of both cell cycle progression and apoptosis. Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathesy related to human malignant tumors. Breast cancer studies have demonstrated a reduction of PTEN expression in advanced breast cancers.
Species Reactivity: Human, Mouse
Clone: BC.6H2.1
Isotypes: IgG
Applications: Formalin-fixed paraffin-embedded tissues
Positive Controls: Breast cancer
Cellular Localizations: Cytoplasmic
Pretreatment Required: Heat Retrieval-Reveal or Diva
Recommended Dilution: 1:200-400
Diluent: Renoir Red
Protocol: 30-10-10
Intended Use: For Research Use Only
Technical Note: