In normal epithelia, HMW Cytokeratins
(CK5 and CK14) stain basal epithelia, in the prostate gland.
p63 is detected in prostate basal
epithelial nuclei in normal prostate, however, is negative in malignant tumors
of the prostate gland. Thus p63 is useful as a differential marker for benign
and malignant tumors of prostate gland and can be useful as a negative
Expression of P504S protein is found in
prostatic adenocarcinoma, but not in benign prostatic tissue. It has also been
found to stain premalignant lesions of the prostate: high-grade prostatic
intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can
be used as a positive marker for PIN. It will be useful to confirm the diagnosis
of small focus of prostate carcinoma in needle biopsies.
The combination of P504S + HMW CKs +
p63 (PIN-4™) may be extremely useful for diagnosing prostatic intraepithelial
neoplasia, especially in difficult cases, and in cases with limited tissues.
P504S stains cytoplasm in prostate adenocarcinoma and atypical adenomatous
hyperplasia, and p63 and HMW CKs stain normal (negative marker) and benign
two-component version (IVD, ASR) can also be purchased:
Prostate-2X (CK5 +
CK14 + p63) Cat. No. PM 364 AAK, HK, JJK (IVD)
p504S-2X Cat. No. PP 365
AA, H, JJ (ASR)