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ROR gamma T (clone 6F3.1) 0.5mL

BC-ACI3208B
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Beskrivning

Retineic-acid-receptor-related orphan nuclear receptor gamma (RORγt) is considered to be one of the master regulators in the development of T helper 17 cells (Th17 cells), which have an essential role in the development of many autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and psoriasis (1). RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ thymocytes. Therefore, RORγt is selectively expressed in the thymus and other immune system tissues although RORγt mRNA is detected in many tissues (2,3). Regulatory T cells can co-express RORγt and FOXP3 and are shown to be both pro-inflammatory and immunosuppressive (4). Studies have also shown a subset of CD8+RORγt+ T cells expressing a low level of PD-1 and a high level of OX40 were associated with reduced patient survival thus CD8+RORγt+ T cells are proinflammatory (5). RORγt seems to be a key regulator of immune homeostasis, proinflammatory, and may have potential for therapeutic targets in inflammatory diseases (6)

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