Produkten har lagts i din varukorg Visa varukorgenTill kassan
Din webbläsare stöds ej. För bästa upplevelsen rekommenderas en nyare version eller en annan webbläsare.
För att ge dig bättre service använder vi cookies. Genom att fortsätta på sidan godkänner du vår användning av cookies.
Melanoma stained with Pan Melanoma antibody

Pan Melanoma Coctail-3 (HMB45, Tyrosinase and MART-1) 5mL

BC-VP165G
Ej i lager
Produktfråga

Vad vill du veta om Pan Melanoma Coctail-3 (HMB45, Tyrosinase and MART-1) 5mL?

Skicka

Beskrivning

Specifications  
Intended Use
Source
Species Reactivity , 
Clone
Isotype
Antigen
Cellular Localization
Positive Control
Normal Tissue
Abnormal Tissue
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. It is also thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels which is specific to melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and Tyrosinase make this quadruple antibody combination a first-order pan melanoma screener, and may prove to be a valuable marker for melanoma metastasis in sentinel lymph nodes.
Läs mer ...Stäng