PTEN (M) 0,1 mL

Specificity and Comments: PTEN gene is a recently discovered tumor supressor gene that maps to chromosome 10q23. It is of longstanding interest to those studying somatic mutations in human tumors. PTEN, a novel tumor supressor, functions as a regulator of both cell cycle progression and apoptosis. Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathesy related to human malignant tumors. Breast cancer studies have demonstrated a reduction of PTEN expression in advanced breast cancers.

Species Reactivity: Human, Mouse

Clone: BC.6H2.1

Isotypes: IgG

Applications: Formalin-fixed paraffin-embedded tissues

Positive Controls: Breast cancer

Cellular Localizations: Cytoplasmic

Pretreatment Required: Heat Retrieval-Reveal or Diva

Recommended Dilution: 1:200-400

Diluent: Renoir Red

Protocol: 30-10-10

Intended Use: For Research Use Only

Technical Note: