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PD-1 0,1 mL


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Programmed death 1 (PD-1) is a cell surface co-receptor in the CD28/CTLA-4 T cell family and functions as a down regulator of the immune system through a dual mechanism of inhibition (1). PD-1 is expressed on the cell surface of activated T- and B-cells. Anti-tumor immunity may be controlled by the PD-1/PD-L1 signaling pathway. PD-L1, one of the ligands associated with PD-1, provides immunity for tumor cells by inducing apoptosis of activated T cells or by inhibiting cytotoxic T cells (1,2). Therapies that target the
PD-1 receptor have shown unprecedented results with high levels of clinical response in patients with various cancer types (3). The presence of PD-1 positive tumor-infiltrating lymphocytes (TIL) has been associated with poor prognosis in human breast cancers and may be useful in antibody therapy targeting the PD-1/PD-L1 signaling pathway (1). Treatments targeting PD-1 and its ligand, PD-L1, have also shown encouraging results in non-small-cell lung cancer, renal cell carcinoma and melanoma (4-6).
FORMAT :                 Concentrate, Predilute
0.1 ml, 1.0 ml, 6.0 ml
SOURCE:                  Mouse Monoclonal
CLONE:                     NAT105
ISOTYPE:                  IgG1/kappa
ANTIGEN:                  PD-1
LOCALIZATION:         Cytoplasmic
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