| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
CD19 |
| ISOTYPE |
IgG1 |
| ANTIGEN |
CD19 |
| LOCALIZATION |
Cytoplasmic/membrane |
| POSITIVE CONTROL |
Tonsil |
CD19 recognizes a 95kD cell surface glycoprotein, which is
expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is
a co-receptor of CD21and is an important signal transduction molecule which is
involved in the regulation of Blymphocyte development, activation and
differentiation. Among the B-cell genes that are present in early B-cell
development and are upregulated by Pax-5 are CD19 and CD79a. CD19 is found in
Pre B cells, B cells (considered a pan B-cell antigen); first B-cell
antigen after HLA-DR and follicular dendritic cells. CD19 is absent in plasma
cells, most T-cell lymphomas and in lymphocyte predomoninant Hodgkin’s. It has
been observed in lymphomas and leukemias but often weak/negative in follicular
lymphoma or diffuse large B-cell lymphoma. CD19 is well-suited for
formalin-fixed paraffin-embedded tissues, flow cytometry and western blotting
techniques. CD19 may provide useful diagnostic information for the study of
B-lymphoproliferative disorders.