Estrogen Receptor 6F11 1,0ml
Specificity and Comments:
The estrogen receptor (ER) is a 66-kDa protein that mediates the actions of estrogens in estrogen-responsive tissues. It is a member of a large superfamily of nuclear-hormone receptors that function as ligand-activated transcription factors. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER? has recently been described. This clone has been established to work in formalin-fixed, paraffin-embedded tissues and has been published in breast cancer research studies. Staining patterns observed include: ER+ and PR+, ER+ and PR-, ER- and PR+, and ER- and PR-. The 6F11 clone has been shown to be superior to the 1D5 (Bevitt DJ et al.).
Species Reactivity: Human; others not tested.
Prokaryotic recombinant protein corresponding to the full-length estrogen receptor molecule
Known Applications: Immunohistochemistry (formalin–fixed paraffin-embedded tissues)
Estrogen receptor positive breast carcinoma
Predominantly nuclear, some cytoplasmic
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.