Estrogen receptor (ER) clone 6F11 is a
66-kDa protein that mediates the actions of estrogens in
estrogen-responsive tissues. The ER gene consists of more than 140kb of
genomic DNA divided into 8 exons. These translate into a protein with six
functionally discrete domains, labeled A through F. This mouse monoclonal
antibody has been established to work in formalin-fixed, paraffin-embedded
tissues and has been published in breast cancer studies. The 6F11 clone has
been shown to be superior to the 1D5 (Bevitt DJ et
al.).