| Specifications |
|
|
| Intended Use
|
IVD |
| Source |
Mouse Monoclonal
, Rabbit
Monoclonal
|
| Species
Reactivity
|
Human, Others not
tested |
| Clone |
CDX2-88 + BC1
|
| Isotype |
IgG, IgG1 |
| Antigen |
CDX2-88 + BC1
|
| Cellular
Localization
|
Cytoplasmic, Nuclear |
| Positive
Control
|
Breast Cancer
, Colon, Lung, Ovarian |
| Normal Tissue
|
Breast, Colon |
| Abnormal
Tissue
|
Breast, Colon, Lung |
CDX2 is a homeobox gene that encodes an
intestine-specific transcription factor. It is expressed in the nuclei of
epithelial cells throughout the intestine, from duodenum to rectum. The CDX2
protein is expressed in primary and metastatic colorectal carcinomas and has
also been demonstrated in the intestinal metaplasia of the stomach and
intestinal-type gastric cancer, while it is not expressed in the normal gastric
mucosa. Studies have shown that CDX2 is a superior marker compared to CK20 and
can be substituted in a panel of antibodies.