Start/Pan Melanoma + Ki-67 25 ml

Pan Melanoma + Ki-67 25 ml

BC-PM362DSH

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Specifications
Intended Use	IVD
Source	Mouse Monoclonal , Rabbit Monoclonal
Species Reactivity	Human, Others not tested
Clone	M2-7C10 + M2-9E3 + T3-11 + SP6
Isotype	IgG2a + IgG2b/kappa + IgG2b/kappa +IgG
Antigen	Melanoma/Ki-67
Cellular Localization	Cytoplasmic, Nuclear
Positive Control	Melanoma
Normal Tissue	Nevus
Abnormal Tissue	Melanoma

This Multiplex application serves as a tool to identify the proliferation rate of melanocytic lesions in cases in which melanocytes are sparse; there are dense lymphocytic infiltrates; and melanocytes are admixed with fibroblasts. In general, a higher proliferative fraction is seen in melanoma than in melanocytic nevi. There are many types of nevi, and some simulate melanoma closely. If the Multiplex stain shows a very low Ki-67 (DAB) labeling rate in MART-1/Tyrosinase positive cells (Fast Red), this favors benignity. A high rate, especially toward the deep part of a melanocytic lesion raises the possibility of malignancy.

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