Thyroglobulin (Cocktail) 0,1 mL

Specificity and Comments:

Recognizes a glycoprotein of 330kDa, identified as thyroglobulin. Antibody to thyroglobulin has been shown to be useful in positive identification of thyroid carcinomas of the papillary and follicular types. BIOCARE’s cocktail of 2H11 and 6E1 antibodies stains thyroglobulin in follicular epithelial cells as well as colloid tissue. Demonstration of thyroglobulin in a metastatic lesion establishes the thyroid origin of the tumor. Adenocarcinomas of non-thyroidal origin are not reactive.

 

 

Known Species Reactivity:

Human, mouse and rat

 

Clone: 2H11+6E1

 

Isotype: IgG1 /IgG1

 

Immunogen: Purified human thyroglobulin

 

Hybridoma:

Produced by the fusion between BALB/c

splenocytes and mouse myeloma Sp2/0 cells

 

Known Applications: Immunohistochemistry

(formalin-fixed paraffin-embedded tissues)

 

Positive Control: Thyroid or thyroid cancer

Cellular Localization:

Cytoplasmic and colloid of follicles

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Product is stable for 18 months.