Terminal
deoxynucleotidyl transferase (TdT) is a nuclear protein widely used as a marker
for lymphoblastic leukemia. Studies have shown that immunohistochemistry
staining can be easily achieved by use of heat retrieval methods in
formalin-fixed paraffin-embedded tissues. Recent studies have shown that a panel
of antibodies consisting of TdT, CD10, CD99 (MIC2), bcl-2 and CD34 can be used
to distinguish lymphoblastic leukemia’s from small noncleaved cell
lymphomas.