TTF-1 0,5 mL

 

Specificity and Comments

TTF-1 recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate and adrenal glands are not reactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas, and is absent in mesotheliomas, colon cancer and breast cancer. TTF-1 can be very useful when used in panel with antibodies CK7, CK20, Villin and CA125.

 

 

 

Species Reactivity: Human, mouse and rat

 

Clone: Clone 8G7G3/1

 

Isotype: IgG1

 

Immunogen:

Rat TTF-1 recombinant protein

 

Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues)

Positive Control:

Lung adenocarcinoma or thyroid

 

Cellular Localization: Nuclear

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.