Spirochete (Treponema pallidum) is the causative agent of
syphilis. Spirochete can now be successfully localized with a treponema pallidum
antibody using immunohistochemical techniques in formalin-fixed,
paraffin-embedded (FFPE) tissue. In the past, localization of the spirochete
agent was achieved with silver stains such as Steiner’s and/or Warthin-Starry.
The spirochete antibody consists of a rabbit purified IgG fraction that is
highly specific. Treponema pallidum antibody also cross-reacts with burgdorferi
(Lyme disease).