| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
6E3 |
| ISOTYPE |
IgG1 /kappa |
| ANTIGEN |
SALL4 (NP_065169, 954 a.a .~ 1054 a.a.)
partial recombinant protein with GST tag. |
| LOCALIZATION |
Nuclear |
| POSITIVE CONTROL |
Seminoma |
SALL4, a newly identified zinc-finger transcriptional
factor, is required for the maintenance of embryonic stem cell pluripotency by
modulating Oct4, and is mapped to chromosome 20q13. SALL4 is a novel sensitive
and specific marker for seminomas and ovarian primitive germ-cell tumors.
Studies demonstrate that over 90% of tumor cells in intratubular germ-cell
neoplasias and embryonal carcinomas show strong SALL4 staining. In one study,
100 percent of all 31 yolk sac tumors (5 pediatric and 26 postpubertal) showed
strong positive SALL4 staining of tumor cells, but were negative for Oct4. This
marker is particularly useful in distinguishing yolk sac tumors from clear cell
carcinomas. SALL4 is a promising new pan germ-cell marker and has been shown to
be superior to PLAP and Oct4
antibodies.