This antibody reacts with Herpes
Simplex Virus (HSV) 1 and 2. It reacts with major viral envelope glycoproteins
and with core proteins. Infected biopsy tissues include esophagus, lung,
liver, cervix and perianal region, as well as cytological prepared cells. HSV
can also infect both the peripheral and central nervous system. Viral
antigens may be detected in the cytoplasm and nucleus. Typically, HSV Type
1, infects tissues such as lung and esophagus and HSV Type 2, infects the
genitals and anus. This antibody does not cross-react with cytomegalovirus,
Epstein-Barr virus, or varicella zoster virus. This antibody works well with
formalin fixation, however prolonged fixation can be detrimental to HSV
staining.