This antibody reacts with human GFAP
and has been solid phase absorbed with human and cow serum. Anti-GFAP stains
astrocytes and some groups of ependymal cells and their corresponding tumors. In
the peripheral nervous system, Schwann cells, enteric glial cells and satellite
cells are stained. Weak staining of axons has been observed which is caused by
cross-reaction with neurofilament. It is useful for distinguishing neoplasms of
astrocytic origin from other neoplasms in the central nervous system. Negative
staining has been observed with lymphatic tissue, muscle, gastrointestinal
tract, liver, kidney, pancreas and
bladder.