| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
R4A |
| ISOTYPE |
IgG1 |
| ANTIGEN |
Smoothelin |
| LOCALIZATION |
Cytoplasmic |
| POSITIVE CONTROL |
Bladder or colon
carcinomas |
Smoothelin is a novel cytoskeletal protein that reacts with the 59
kDa and 100 kDa protein, corresponding to Smoothelin A and B, respectively,
which are exclusively found in smooth muscle cells (SMC). Cells with SMC-like
characteristics, such as myofibroblasts and myoepithelial cells, as well as
skeletal and cardiac muscle do not contain Smoothelin. Smoothelin is exclusively
expressed in fully differentiated (contractile) smooth muscle cells such as
human detrusor and in the human muscularis propria. Studies have also shown
Smoothelin as a potential tool in the pathologic staging of invasive urothelial
carcinoma, overactive bladder, and in the evaluation of atherosclerotic
lesions.