Cytokeratin 7 0,1ml

Specificity and Comments:

Cytokeratin 7 is an intermediate filament protein (IFP) of 54kDa that recognizes simple epithelium found in most glandular and transitional epithelia, but not in the stratified squamous epithelia. This monoclonal antibody [clone K72.7] is highly specific to cytokeratin 7 and shows no cross-reaction with other IFPs. Cytokeratin 7 is a basic cytokeratin, and is expressed in epithelial cells of ovary, lung, and breast, but not of colon or gastrointestinal tract. It is often used in conjunction with cytokeratin 20 in distinguishing ovarian, pulmonary, and breast carcinomas (CK7+) from colon carcinomas (CK7-).

 

 

Species Reactivity: Human; others not tested.

 

Clone: K72.7

 

Isotype: IgG1

 

Immunogen:

Semi-purified cytokeratin preparation

 

Known Applications: Immunohistochemistry (formalin–fixed paraffin-embedded tissues)

 

 

Positive Control: Ovarian and breast cancer.

 

 

Cellular Localization: Cytoplasmic

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.