Cytokeratin 5 antibody rabbit is a type II intermediate filament
protein that is expressed in active basal layers of most stratified squamous
epithelia. CK5 is expressed in many non-keratinizing stratified squamous
epithelia as well as basal cells in prostate glands and myoepithelial cells in
mammary glands. In a published study, rabbit monoclonal CK5 antibody was
compared to mouse monoclonal CK5/6. CK5 was 84% sensitive and 100% specific for
lung SqCC when compared to CK5/6 (80% sensitivity and 97% specificity). The CK5
predilute has been optimized for lung squamous cell carcinoma; other tumors have
not been tested.