Cytokeratin 20 0,1 mL

Specificity and Comments:

Cytokeratin 20 is 46kDa intermediate filament protein that has been identified with expression primarily restricted to gastric and intestinal epithelium, urothelium, and Merkel cells. CK20 [clone Ks20.8] is highly specific to cytokeratin 20 and shows no cross-reaction with other IFPs. Cytokeratin 20 is a unique type I keratin that is expressed in adenocarcinomas of the colon stomach, pancreas and bile system. It is also expressed in mucinous ovarian tumors, transitional cell carcinomas of the urinary tract, and Merkel cell carcinomas. CK20 is essentially non-reactive in squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas. Cytokeratin 20 is often used in conjunction with CK7 and other antibodies in distinguishing colon carcinomas (CK20+), from ovarian, pulmonary, and breast carcinomas.

 

 

Species Reactivity: Human; others not tested.

 

Clone: Ks20.8

 

Isotype: IgG2a

 

Immunogen:

Cytoskeletal preparation from microdissected villi of human duodenal mucosa

 

Known Applications: Immunohistochemistry

(formalin–fixed paraffin-embedded tissues).

 

 

 

Positive Control: Colon carcinoma.

 

Cellular Localization: Cytoplasmic

 

Supplied As:

Buffer with protein carrier and preservative

*Includes Van Gogh Yellow Diluent (PD902JJ)

**Includes Van Gogh Yellow Diluent (PD902H)

 

Storage and Stability:

Store vial at 4°C. Antibody is stable for 18 months.