This
rabbit monoclonal antibody recognizes a protein of 36kDa, identified as cyclin
D1 (also known as bcl-1 or PRAD-1). Cyclin D1 is a regulatory subunit of certain
protein kinases thought to advance the G1 phase of the cell cycle. Cyclin D1
used in tandem with CD5, CD10 and CD23 is the most reliable immunohistochemical
marker for the mantle cell lymphoma. Cyclin D1 is also expressed in invasive
breast cancer. Due to the superior technology in the development of this
antibody, its binding capacity is superior to mouse monoclonal antibodies
and is virtually background free.