ChromograninA Cocktail 0,1 mL

Specificity and Comments:

Recognizes a protein of 68-75kDa, identified as chromogranin A (a protein of 439-amino acid which is encoded on chromosome 14). Although the epitopes for [LK2H10] and [PHE5] are not precisely mapped, experimental data suggest that they are different (a cocktail of LK2H10 and PHE5) is especially designed for sensitive detection of Chromogranin A in formalin-fixed, paraffin-embedded tissues. Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

 

 

Species Reactivity: Human and Monkey

 

Clone: LK2H10 + PHE5

 

Isotype: IgG1 + IgG1

 

Immunogen: Human pheochromocytoma

 

Hybridoma:

Produced by fusion between BALB/c splenocytes and myeloma p3-NS1-Ag4-1 cells.

 

Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded)

Positive Control:

Pancreas, adrenal gland, bowel, thyroid

Cellular Localization:

Finely granular cytoplasmic

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.