Cytokeratin
7 is an intermediate filament protein (IFP) of 54kDa that recognizes the simple
epithelium found in most glandular and transitional epithelia; but not that
which is found in the stratified squamous epithelia. This rabbit monoclonal
antibody [clone BC1] is highly specific to cytokeratin 7 and shows no
cross-reaction with other IFPs. Cytokeratin 7 is expressed in epithelial cells
of ovary, lung and breast. It is often used in conjunction with cytokeratin 20
and CDX-2 in distinguishing pulmonary, ovarian and breast carcinomas (CK7+) from
most colon carcinomas (CK7-).