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Tonsil stained with CD68 antibody

CD68 (Macrophage) (KP1) 0,1mL

BC-CM033A
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CD68 (Macrophage) (KP1) 0,1mL
Specificity and Comments:
The CD68 antigen is a 110 kDa highly glycosylated transmembrane protein which is mainly located in lysosomes. The antibody stains macrophages in many human tissues including Kupffer’s cells and macrophages in the red pulp of the spleen, in lung alveoli, in lamina propria of the gut, and in the bone marrow. Antigen-presenting cells are either negative or show weak and/or restricted areas of reactivity. Peripheral blood monocytes are also positive with granular staining pattern. The antibody reacts with myeloid precursors and peripheral blood granulocytes. In addition, the antibody reacts with plasmacytoid T-cells that are present in many reactive lymph nodes, and are believed to be of monocyte/macrophage origin. The antibody marks the malignant cells in chronic and acute myeloid leukemia. A positive staining of normal and neoplastic mast cells is seen with the antibody, as well as staining of a variable number of cells in malignant melanomas. Studies have shown that CD68 (KP1) is formalin-sensitive and false negatives can occur without proper pretreatment. We highly recommend a heat-induced epitope retrieval (HIER) method versus enzyme digestion.
 
 
Known Species Reactivity: Human
 
Clone: KP1
 
Isotype: IgG1/?
 
Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues)
 
Positive Control: Tonsil
 
Cellular Localization: Cytoplasmic
 
Supplied As:
Buffer with protein carrier and preservative
 
Storage and Stability:
Store vial at 4°C. Stable for 18 months.
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