CD5 (4C7) 0,1ml

Specificity and Comments:

CD5 is a T-cell associated marker that is also expressed by two B-cell neoplasms, lymphocytic leukemia and mantle cell lymphoma. CD5 antigen is expressed in 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, CD5 is mainly reactive with T-cells. It has been shown to react with thymic carcinomas and rarely in thyomas. It has also been observed in a subset of intravascular large B-cell lymphomas and marks some anaplastic large cell lymphomas. CD5 has proven very useful in marking mantle cell lymphoma when used in tandem with CD23, cyclin D1, and IgM (CD23 is negative and CD5, cyclin D1 and IgM are positive for mantle cell lymphoma).

 

 

Species Reactivity: Human; other not tested.

 

Clone: 4C7

 

Isotype: IgG1,?

 

Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues)

 

 

Positive Control: Mantle cell lymphoma

 

Cellular Localization: Cell membrane

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.