| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| ISOTYPE |
IgG2a |
| ANTIGEN |
CD30 |
| LOCALIZATION |
Cell Membrane |
| POSITIVE CONTROL |
Hodgkin’s or anaplastic large cell lymphoma |
| CLONE |
CON6D/B5 |
The Ki-1 antigen, recognizes a single chain transmembrane
glycoprotein that has been demonstrated to be homologous to members of the nerve
growth factor receptor superfamily. The mature 120 kDa molecule is formed from
90 kDa precursor molecule processed in the Golgi system. The Ki-1 (CD30) antigen
is expressed in mononuclear Hodgkin’s and multinucleated Reed-Sternberg cells in
Hodgkin’s disease. It is expressed by the tumor cells of a majority of
anaplastic large cell lymphomas, and by a varying proportion of activated T and
B cells. CD30 is also expressed in embryonal carcinomas. It distinguishes large
cell lymphomas derived from activated lymphoid cells, from histiocytic
malignancies and lymphomas derived from resting and precursor lymphoid cells, or
from anaplastic carcinomas. CD30 and CD15 primary antibodies may be used in
tandem to differentiate between anaplastic large cell lymphoma and Hodgkin’s
disease (Reed-Sternberg cells).