| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
MS110 |
| ISOTYPE |
IgG1 |
| ANTIGEN |
BRCA-1 |
| LOCALIZATION |
Nuclear |
| POSITIVE CONTROL |
Breast cancer |
The BRCA-1 gene codes for a nuclear phosphoprotein that plays a
role in maintaining genomic stability and acts as a tumor suppressor. The
normal gene plays a role in repairing breaks in DNA. If a mutation occurs
in this gene the repair function may become disabled thus leading to more
DNA replication errors and neoplastic growth. Current findings suggest that
BRCA-1 may play an as yet undefined protective role in cells, as it is
strongly expressed in epithelial cells undergoing high levels
of proliferation in association with differentiation. Additional findings
have determined that complete loss of BRCA-1 nuclear expression in breast
cancer and the correlation with poor prognostic markers imply that the
altered BRCA-1 phenotype may provide an added prognostic parameter for
breast cancer and could be applied for a potential rapid screening
technique to identify BRCA-1 mutations.