BOB-1 Ready to use
BOB-1 antibody is a B-lymphocyte-specific transcriptional co-activator for Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 are useful for the B-lineage determination of CD20-plasmablastic or primary effusion subtypes of diffuse large B-cell lymphoma (DLBCL). Other studies have shown BOB-1, CD79a and Cyclin E are useful markers for discriminating classical Hodgkin’s lymphoma from primary mediastinal large B-cell lymphoma. The strong nuclear expression of BOB-1 and Oct-2 by germinal center derived lymphomas makes these antibodies a novel class of broad spectrum B-lineage IHC markers to aid in the differential diagnosis of lymphomas.
INTENDED USE |
IVD
|
SPECIES REACTIVITY |
Human
|
SOURCE |
Mouse Monoclonal
|
CLONE |
TG14
|
ISOTYPE |
IgG1
|
ANTIGEN |
Prokaryotic recombinant protein containing 116 amino acids of the C-terminus of BOB-1
|
LOCALIZATION |
Nuclear
|
POSITIVE CONTROL |
Tonsil
|