| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
156-3C11 |
| ISOTYPE |
IgG2a |
| ANTIGEN |
CD44 |
| LOCALIZATION |
Cytoplasmic/cell membrane |
| POSITIVE CONTROL |
Breast cancer or
tonsil |
CD44 antigen is a transmembranous glycoprotein (80 kDa) antibody
that is specific for epitope 3 of the CD44 H molecule. CD44 (HCAM) is a cell
adhesion molecule that plays an important role in the cascade of metastasis and
progression of human malignant tumours. CD44 antigen is present on T
lymphocytes, granulocytes, red blood cells, brain and epithelial cells. The
standard isoform, CD44s, are also expressed in a wide range of normal tissues
such as tonsil, skin, bladder and cervical squamous epithelium. In breast cancer
studies, CD44 expression, as assessed by immunohistochemical staining
demonstrated a favorable prognostic factor in patients with node-negative
invasive breast carcinoma. Further studies have shown a subpopulation of
CD44+/CD24- in breast cancer cells have stem/progenitor cell
properties.