In normal epithelia,
HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63
is detected in prostate basal epithelial nuclei in normal prostate, however, is
negative in malignant tumors of the prostate gland. Thus p63 is useful as a
differential marker for benign and malignant tumors of the prostate gland and
can be useful as a negative marker. Prostate – 2X can be used in combination
with an additional antibody to generate a PIN-4 combination (see technical
notes).
INTENDED
USE
|
IVD |
SPECIES
REACTIVITY
|
Human |
SOURCE |
Mouse
Monoclonal
|
CLONE |
XM26/LL002 +
4A4
|
ISOTYPE |
IgG1/kappa IgG3
IgG2a/kappa
|
ANTIGEN |
CK5 CK14
p63
|
LOCALIZATION |
Cytoplasmic and
nuclear
|
POSITIVE
CONTROL
|
Normal
prostate
|