This
rabbit monoclonal antibody reacts with the intracytoplasmic portion of the CD3
antigen expressed by T cells. It stains human T-cells in both the cortex and
medulla of the thymus and in peripheral lymphoid tissues. It does not react with
B-cells, monocytes, granulocytes and platelets. CD3 is regarded as a reliable
pan T-cell antibody used in the immunophenotyping of T-cell lymphomas in
paraffin sections. CD3 does not react with B-cells. Most T-cell lymphomas show
positivity for CD3. Used in conjunction, CD3 and UCHL-1 together identified the
vast majority of T-cell lymphomas in paraffin
sections.