This rabbit monoclonal antibody
recognizes a protein of 36kDa, identified as cyclin D1 (also known as bcl-1 or
PRAD-1). Cyclin D1 is a regulatory subunit of certain protein kinases thought to
advance the G1 phase of the cell cycle. Cyclin D1 used in tandem with CD5, CD10
and CD23 is the most reliable immunohistochemical marker for the mantle cell
lymphoma. Cyclin D1 is also expressed in invasive breast cancer. Due to the
superior technology in the development of this antibody, its binding capacity is
superior to mouse monoclonal antibodies and is virtually background
free.