Phospho-Histone H3
Phospho-Histone H3 antibody (pHH3) is an immunomarker specific for cells
undergoing mitosis. The phosphorylation of histone H3 plays an important role in
gene expression, chromatin remodeling, chromosome condensation and cell
division. Across different organisms, metaphase chromosomes are always found to
be heavily histone H3 phosphorylated. Determination of the mitotic index using
pHH3 has been reported to be of prognostic significance in breast cancer,
melanoma and meningiomas. pHH3 immunostaining may also provide an accurate
proliferation potential which can be relevant to tumor
grading.
INTENDED
USE
IVD
SPECIES
REACTIVITY
Human
SOURCE Rabbit
Polyclonal
CLONE N/A
ISOTYPE
N/A
ANTIGEN
PhosphoSer10.
LOCALIZATION
Nuclear
POSITIVE
CONTROL
Melanoma