Tyrosinase (T311) 0,5 mL
Specificity and Comments
Tyrosine is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, tyrosinase or MART-1 does not discriminates between activated or resting melanocytes. Other studies have shown tyrosinase to be a very specific marker for melanomas, and did not cross react with any tumors or normal tissues tested. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45.
Species Reactivity: Human; others not tested.
Clone: T311
Isotype: IgG2a
Immunogen: Recombinant tyrosinase protein
Known Applications: Immunohistochemistry
(formalin-fixed paraffin-embedded tissues)
Positive Control: Melanoma
Cellular Location: Cytoplasm
Supplied As:
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months