Androgen Receptor (AR441) 0,1mL
Specificity and Comments:
The androgen receptor antibody recognizes the protein of 110kDa molecular weight. It reacts with full length and A form of the receptor. It is highly specific and does not cross-react with estrogen, progesterone and glucocorticoid receptors. The expression of AR is reportedly inversely correlated with poorly differentiated tumors (well-differentiated tumors show high expression of AR and poorly-differentiated tumors show low or no expression of androgen receptor. In prostate cancer, androgen has been proposed as a marker of hormone-responsiveness similar to estrogen receptor and breast cancer, thus high expression of androgen receptor in prostate cancer biopsies may help identify patients that would respond anti-androgen therapy. Other applications for androgen receptor include breast cancer, Paget’s disease and dermatopathology.
Species Reactivity: Human; others not tested.
Clone: AR441
Isotype: IgG1
Immunogen:
KLH conjugate of a synthetic peptide human androgen receptor
Known Applications: Immunohistochemistry
(formalin–fixed paraffin-embedded tissues)
Positive Control:
Prostate cancer or normal prostate
Cellular Localization: Nuclear
Supplied As:
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.