The
oncogene-encoded protein c-Myc is postulated to play a role in activating the
transcription of growth related genes. Amplification of the c-Myc gene has been
found in several types of human tumors. Studies have shown that c-Myc is
essential for vasculogenesis and angiogenesis in neoplastic disease. c-Myc
oncogene activity may also be necessary for the translocation(s) seen in human
breast tumors identified to have a poor-prognosis signature. Over-expression of
the c-Myc oncogene has been implicated in the development and progression of
human prostate carcinoma.
INTENDED
USE |
IVD |
SPECIES
REACTIVITY |
Human |
SOURCE |
Rabbit
Monoclonal |
CLONE |
Y69 |
ISOTYPE |
IgG |
ANTIGEN |
Synthetic
peptide corresponding to residues in N-terminus of human c-Myc |
LOCALIZATION |
Nucleus |
POSITIVE
CONTROL |
Some
prostate or breast
cancer |