Desmin 1,0 ml

Specificity and Comments:

Desmin recognizes a 53kDa intermediate filament protein which is identified as desmin. This MAb is highly specific to desmin and shows no cross-reaction with other intermediate filament proteins. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the Z-bands giving a characteristic striated appearance. Anti-desmin antibody is useful in identification of tumors of myogenic origin. It reacts with leiomyosarcomas (smooth muscle) as well as rhabdomyosarcomas (striated muscle). BIOCARE’S D33 MAb is excellent for staining of formalin-fixed paraffin-embedded tissues.

 

 

Species Reactivity:

Human, baboon, monkey, cow, cat, dog,

hamster, rat, and chicken.

 

Clone: D33

 

Isotype: IgG1 / ?

 

Immunogen: Desmin purified from human muscle

 

Known Applications: Immunohistochemistry (formalin-fixed paraffin embedded tissues)

Positive Control: Leiomyosarcoma

 

Cellular Localization: Cytoplasmic

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.