| INTENDED USE |
IVD |
| SPECIES REACTIVITY |
Human |
| SOURCE |
Mouse Monoclonal |
| CLONE |
6E3 |
| ISOTYPE |
IgG1 /kappa |
| ANTIGEN |
SALL4 (NP_065169, 954 a.a .~ 1054 a.a.)
partial recombinant protein with GST tag. |
| LOCALIZATION |
Nuclear |
| POSITIVE CONTROL |
Seminoma |
SALL4, a newly identified zinc-finger transcriptional factor, is required
for the maintenance of embryonic stem cell pluripotency by modulating Oct4, and
is mapped to chromosome 20q13. SALL4 is a novel sensitive and specific marker
for seminomas and ovarian primitive germ-cell tumors. Studies demonstrate that
over 90% of tumor cells in intratubular germ-cell neoplasias and embryonal
carcinomas show strong SALL4 staining. In one study, 100 percent of all 31 yolk
sac tumors (5 pediatric and 26 postpubertal) showed strong positive SALL4
staining of tumor cells, but were negative for Oct4. This marker is particularly
useful in distinguishing yolk sac tumors from clear cell carcinomas. SALL4 is a
promising new pan germ-cell marker and has been shown to be superior to PLAP and
Oct4 antibodies.