Tyrosinase (T311) 1,0 mL

Specificity and Comments

Tyrosine is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, tyrosinase or MART-1 does not discriminates between activated or resting melanocytes. Other studies have shown tyrosinase to be a very specific marker for melanomas, and did not cross react with any tumors or normal tissues tested. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45.

Species Reactivity: Human; others not tested.

Clone: T311

Isotype: IgG2a

Immunogen: Recombinant tyrosinase protein

Known Applications: Immunohistochemistry

(formalin-fixed paraffin-embedded tissues)

Positive Control: Melanoma

Cellular Location: Cytoplasm

Supplied As:

Buffer with protein carrier and preservative

Storage and Stability:

Store vial at 4°C. Stable for 18 months