p53 acts both as a tumor-suppressor and
transcription factor. Activation by DNA damage or other stress signals triggers
cell-cycle arrest, apoptosis and DNA repair. The nuclear p53 gene is located on
chromosome 17p, a frequent site of allele loss in many tumors (60%) including
breast, colon and lung. This high affinity p53 rabbit monoclonal is very
specific and is superior to other p53 mouse monoclonal antibodies. This antibody
recognizes both wild-type and mutant p53.