PAX-5 (Pan B Cell) 0,1 mL

Specificity and Comments:

PAX-5 is a B-cell specific activator protein (BSAP). In early stages of B-cell development, PAX-5 influences the expression of several B-cell specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. There is an excellent correlation between CD20 and Pax-5 expression; however anti-Pax-5 exceeds the specificity and sensitivity of L26 (CD20) because of its earlier expression in B-cell differentiation and its ability to detect all committed B cells, including classic Hodgkin’s lymphoma. It is very specific to B-cell lineage and does not stain T cells. In essence, PAX-5 may be a superior pan B-cell marker than CD20 (see reference).

Species Reactivity:

Human and mouse; others not tested

Clone: BC/24

Isotype: IgG1

Known Applications: Immunohistochemistry

(formalin–fixed paraffin-embedded tissues)

Positive Control: Tonsil

Cellular Localization: Nuclear

Supplied As:

Buffer with protein carrier and preservative

Storage and Stability:

Store vial at 4°C. Stable for 18 months.