p63 1,0 mL

Specificity and Comments:

p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. P63 is detected in prostate basal cells in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of prostate gland and can be used in a panel of antibodies such as HMW CK (34ßE12), PSA and PSAP. P63 may play a significant role in prostate development by maintaining a prostate stem cell population. Striated muscle staining may be observed with p63.

Species Reactivity: Human, mouse and rat

Clone: BC4A4

Isotype: IgG2a /?

Immunogen:

Recombinant human protein derived from aa 1-205 of human p63

Known Applications: Immunohistochemistry (formalin–fixed paraffin-embedded tissues).

Positive Control: Normal prostate

Cellular Localization: Nuclear

Supplied As:

Buffer with protein carrier and preservative

Storage and Stability:

Store vial at 4°C. Stable for 18 months.