Microphthalmia
Transcription Factor antibody (MiTF) is a nuclear melanocytic marker. Studies
have shown it is a sensitive and specific marker for malignant melanoma,
including some spindle-cell variants. MiTF has been shown to have superior
sensitivity and specificity to S100 and HMB45. MiTF may be useful for
identification of melanoma, melanocytic soft tissue tumors and the unusual group
of tumors that show combined melanocytic and myloid differentiation, the
perivascular epithelioid cell family of tumors (PEComas). Microphthalmia
Transcription Factor may be a valuable addition to a melanoma marker panel with
S-100, HMB45, Tyrosinase and MART-1.