MSH6 0,1 mL

Specificity and Comments:

MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispairs insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations in MSH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.

Species Reactivity: Human and mouse

Clone: BC/44

Isotype: IgG1

Known Applications: Immunohistochemistry (formalin–fixed, paraffin embedded tissues)

Positive Control: Tonsil or colon cancer

Cellular Localization: Nuclear

Supplied As:

1. Buffer with protein carrier and preservative

2. BORGDECLOAKER (BD1000S-250)

Storage and Stability:

Store vial at 4°C. Stable for 18 months.