MART-1 cocktail 0,5ml

 

Specificity and Comments

The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T- cells 1) or Melan-A. The MART-1 recognizes a subcellular fraction found in melanosomes. The antibody labels melanomas and tumors showing melanocytic differentiation. It does not mark neoplasms of epithelial origin, lymphomas or mesenchymal tumors. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Both HMB-45 and MART-1 are coexpressed in the majority of melanomas, as well as uniquely expressed in certain cases. Studies have shown that MART-1 is more sensitive than HMB-45 when labeling metastatic melanomas.

 

 

Species Reactivity: Human, mouse and rat.

 

Clone: M2-7C10 + M2-9E3

Isotypes: IgG2b and IgG2b

 

Immunogen:

MART-1 - Recombinant hMart-1 protein

 

Known Applications: Immunohistochemistry

(formalin-fixed paraffin-embedded tissues)

Positive Control: Melanoma

 

Cellular Location: Cytoplasmic

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.