NKX3.1 (D2Y1A) 0.5mL

Specifications

NKX3.1 is located in chromosome 8p and encodes a homeodomain transcription factor whose expression is largely restricted to the prostate and controlled by the androgen hormone.¹ Loss of function of NKX3.1 results in human prostrate carcinoma and prostatic intraepithelial neoplasia (PIN). NKX3.1 stains nuclei in both normal and prostate cancer providing a robust stain that is easy to interpret.² Studies show that NKX3.1 is highly sensitive and specific for high-grade prostatic adenocarcinoma and highly sensitive for metastatic prostatic adenocarcinoma. The sensitivity for identifying metastatic prostatic adenocarcinomas overall was 98.6% (68/69 cases positive) for NKX3.1 compared to 94.2% (65/69 cores positive) for PSA. In the appropriate clinical setting, the addition of IHC staining for NKX3.1, along with other prostate-restricted markers, may help to definitively determine prostatic origin in poorly differentiated metastatic carcinomas.³

^{Download Data Sheet}